This course teaches laboratory personnel how to recognize, store, handle, and respond to flammable, combustible, explosive, and reactive hazards in laboratory environments. Participants will learn that fire and explosion hazards often begin with ordinary conditions: open solvent bottles, vapor accumulation, poor storage decisions, incompatible chemicals, static discharge, aging peroxide-forming solvents, or unrecognized ignition sources. The course connects OSHA regulatory requirements with practical laboratory safety decisions.